Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Science Bulletin》 2015-12
Add to Favorite Get Latest Update

The design and application of functionalized mesoporous silica nanocarrier

LUO GuoFeng;CHEN WeiHai;ZHUO RenXi;ZHANG XianZheng;Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University;  
With the rapid development of nanotechnology, nanomaterials with unique physical and chemical characteristics, have offered tremendous potential for biomedical application. Among them, mesoporous silica nanoparticles(MSNs), a class of well-established nanoplatforms with different structures and compositions, have been widely used to develop drug delivery systems owing to their unique physical-chemical properties, such as tunable particle/pore size, high surface area and pore volume, easy surface modification, remarkable stability and biocompatibility, and high drug loading efficiency. Moreover, MSN-based nanocarriers with "zero premature release" property have proven to be excellent devices for drug delivery. A variety of fluorescent dyes and pharmaceutical drugs were encapsulated in MSNs for controlled release. In addition, numerous efforts have been made to develop smart nanovalves on the surface of MSN to provide on-command release of drug in response to different stimuli, including light, enzymes, p H, redox, temperature, and competitive molecules. Furthermore, the outer surface of MSN can be modified with various functional groups, that play critical roles(stealth or targeting) in overcoming the multistage barriers found in the drug delivery process. Fabrication of MSN-based, multifunctional, stimuli-responsive drug delivery systems can effectively encapsulate anticancer drugs and can maintain "zero premature release" before reaching the diseased site. Once they arrive at the tumor site with the aid of targeting groups, the nanodevice can be activated by a specific stimulus to release the drug. The delivery of anticancer drugs to a specific target site can alleviate toxic side effects and improve the therapeutic index of drugs; thus, achieving significantly enhanced anticancer efficiency. Herein, we reviewed various strategies for the design of stimuli-responsive, MSN-based drug delivery systems, and multifunctional MSN for targeted cancer therapy.
【Fund】: 国家自然科学基金(51125014 51233003);; 武汉大学博士研究生自主科研基金(2014203020201 2014203020204)资助
【CateGory Index】: TB383.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Ke-Ni Yang;Chun-Qiu Zhang;Wei Wang;Paul C.Wang;Jian-Ping Zhou;Xing-Jie Liang;State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University;CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences;Laboratory of Molecular Imaging, Department of Radiology, Howard University;;pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment[J];癌症生物学与医学(英文版);2014-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XIE Xiang-yang;LIN Wen;LI Yang;LI Yin-ke;CHEN Ying;Department of Pharmacy,Wuhan General Hospital of Guangzhou Military Command;Department of Clinical Laboratory,Huangshi Love and Health Hospital of Hubei Province;;Design and construction of stimuli-responsive nanoparticulate drug delivery systems: research advances[J];Journal of International Pharmaceutical Research;2013-05
2 YU Sha-wei;PAN Ai-ping;CHENG Wei-qing;Fujian Vocational College of Bioengineering;;Fluorescence Quenching Method for the Determination of Metallic Ions with L-Cys-CdS Nanoparticles as Fluorescent Probes Prepared by Microwave Irradiation[J];Journal of Fujian Normal University(Natural Science Edition);2014-02
3 Quan Zhang;Zhou Ye;Shu-Ting Wang;Jian Yin;The Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministry of Education,School of Biotechnology,Jiangnan University;;Facile one-pot synthesis of PEGylated monodisperse mesoporous silica nanoparticles with controllable particle sizes[J];中国化学快报(英文版);2014-02
4 LI Na;CHEN Wei;LI Hongxia;Department of Gynecology and Obstertrics,Affiliated Beijing Shijitan Hospital of Capital Medical University;;Study on pharmacokinetics of folic acid coupling nanometer paclitaxel liposome in rats[J];Chinese Journal of Clinical Obstetrics and Gynecology;2014-02
5 Xi-hong Xing;Rong-hui Lai;Ping-jiang Dong;Jian-bin Luo;College of Chemistry and Environment Protection Engineering,Southwest University for Nationalities;;Preparation and Characterization of Redox-responsive Polyurethane Micelles[J];Acta Polymerica Sinica;2014-05
6 Ke-Ni Yang;Chun-Qiu Zhang;Wei Wang;Paul C.Wang;Jian-Ping Zhou;Xing-Jie Liang;State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University;CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences;Laboratory of Molecular Imaging, Department of Radiology, Howard University;;pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment[J];癌症生物学与医学(英文版);2014-01
7 Olga B.Garbuzenko;Gediminas Mainelis;Oleh Taratula;Tamara Minko;Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;Department of Environmental Sciences, Rutgers, The State University of New Jersey;Environmental and Occupational Health Sciences Institute;Department of Pharmaceutical Sciences, Oregon State University;Rutgers Cancer Institute of New Jersey;;Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention[J];癌症生物学与医学(英文版);2014-01
8 LI Chengfeng;GAO Tianyu;HE Liqun;LU Hao;GE Xiaolu;School of Materials Science and Engineering,Shandong University of Technology;School of Science,Shandong University of Technology;;Synthesis and in Vitro Release Behavior of Core-Shell Structured Hydroxyapatite/Mesoporous Silica Powders with Drug Storage[J];Journal of the Chinese Ceramic Society;2014-04
9 WANG Xin-ran;DI Wen;Department of Obstetrics and Gynecology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai Key Laboratory of Gynecologic Oncology,Shanghai Education Commission Key Disciplines Foundation;;The Applications of Mesoporous Silica Nanoparticles in Cancer Diagnosis and Therapy[J];Journal of International Obstetrics and Gynecology;2014-02
10 SUN Xiaocheng;YANG Hao;WANG Jianzu;MA Rujiang;AN Yingli;SHI Linqi;Key Laboratory of Functional Polymer Materials,Ministry of Education,Institute of Polymer Chemistry,Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Nankai University;;Dual-responsive Micelles Based on Boronicacid-modified Polymer[J];Chemical Journal of Chinese Universities;2014-07
China Proceedings of conference Full-text Database 4 Hits
1 Mingjun Gao;Qin Cong;Bo Zhang;Xiaochun He;Xingfa Ma;Guang Li;School of Environmental and Material Engineering,Yantai University;State Key Laboratory of Silicon Materials,Zhejiang University;National Laboratory of Industrial Control Technology,Institute of Cyber-Systems and Control,Zhejiang University;;Tailoring the intelligent properties of Low-dimensional functional materials using grafting copolymer and its soft/hard interface of organic-inorganic nanocomposites[A];[C];2014
2 Jianlin Shi;State key lab. of high performance and superfine microstructure,Shanghai institute of ceramics,Chinese academy of sciences;;MSNs-mediated drug delivery for cancer therapy[A];[C];2014
3 Guangbao Yang;Hua Gong;Xiaoxin Qian;Pengli Tan;Youyong Li;Zhuang Liu;Functional Nano&Soft Materials Laboratory (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices,Soochow University;;Mesoporous Silica Nanorods Intrinsically Doped with Photosensitizers as a Multifunctional Drug Carrier for Combination Therapy of Cancer[A];[C];2014
4 Shengwang Zhou;Shanshan Wu;Xuan Huang;Xuezhong Du;School of Chemistry and Chemical Engineering,Nanjing University;;Construction and Controlled Release of Biomacromolecule-Gated Mesoporous Silica Drug Delivery Systems[A];[C];2014
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved