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《Chinese Science Bulletin》 2015-30
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Influence of diet on autism

DUAN YunFeng;WU XiaoLi;JIN Feng;Key Laboratoory of Mental Health,Institute of Psychology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;  
Autism is a heterogeneous group of neurodevelopmental disorders,characterized by severe behavioral abnormalities,language and social communication difficulties,and unusually restricted,repetitive behaviors and interests. Some autistic children cannot take care of themselves,and the course of the disease may last for the person's lifetime. The prevalence of diagnosed autism has rapidly increased over the last several decades,and the disorder has caused a serious social and economic burden to patients' families and the society at large. The etiology and mechanism of autism are most likely the result of complex interactions between genetic and non-genetic risk factors. However,these are yet to be completely elucidated and effective treatment methods or interventions are required. The present research shows a close association between diet and autism,poor eating habits,harmful substances from food,abnormalities in nutrient absorption,and utilization and metabolism; all of these may affect the immune,endocrine,and metabolic systems,and finally affect brain development. The intestinal microbiota is significantly influenced by diet and is essential for human health. In particular,it can affect the brain's normal operation and development through the microbiome-gut-brain axis. Nutrients,growth-promoting substances,and microbes in the diet provide adequate material base for the growth and maintain the composition of the intestinal microbiota. An intervention in the diet may not only improve the nutritional status of autistic patients but also relieve some gastrointestinal symptoms as well as improve sleep,inflexibility,self-injuring behavior,hyperactivity,irritability and other abnormal behaviors; in addition,social and language skills are also improved. Specifically after probiotic treatment,the intestinal microbiota and autism-like behaviors are all significantly improved. Therefore,as autism causes widespread concern,probiotic interventions and the relationship between diet,intestinal microbiota,and autism are becoming research hotspots.
【Fund】: 中国博士后科学基金(2013M541072);; 日本NS BIO JAPAN株式会社;; 广东新日生物科技有限公司资助
【CateGory Index】: R749.94;R459.3
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