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Cross susceptability of ototoxicity about aminoglycoside antibiotics

Wu Jing(Military General Hospital,Jinan, 250031)  
A familial investigation was made in three families with deafness patients caused by aminoglycoside (AMI). The results showed that there was cross susceptatility among a few AMI antibiotics. The people with familial history of deafness caused by AMI were easier to be toxic than those without familial history,even though little dose of AMI for the former,especially for chil-dren. The cross susceptebility is dominated by inheritance of matriarchal heredity and by general chromosome. The data suggest that medical history should be inquired be fore treatment with AMI,and patients with matriarchal heredity must be prohibited from using AMI.
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