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《Journal of Clinical Otorhinolaryngology》 2006-01
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The effects of EPHPH on acoustic brainstem response threshold and its relative factors of senile model rats

YUAN Yiming1 GE Bin2 XU Aixia2 GAO Xiang2 ZHANG Zhenming2 (1Department of Otolaryngology,Second Affiliated Hospital of Lanzhou Medical College, Lanzhou,730030,China;2Department of Pharmaceutics,People's Hospital of Gansu Province)  
Objective:The effect of EPHPH on aged deafness and its mechanism was explored by observing the effects of EPHPH on acoustic brainstem response threshold(ABRT),malondialdehyde(MDA), superoxide dismutase(SOD), total-nitrogen monoxide(NOS) and typing-nitrogen monoxide(iNOS) in cochleae tissues of senile model rats.Method:ABRT value was measured by induced potentiometer,MDA was measured by TBA colorimetry,SOD was determined by nitrite method, NOS and iNOS was determined by spectrophotometry in cochleae tissues of senile model rats that separately administered by gavage the alcoholic extract from 2.16, 4.32 or 8.64 g·kg -1·d -1 PHPH once a day for 6 months.Result:ABRT value and MDA content notably increased, activities of SOD, NOS and iNOS notably decreased in cochlear tissues of senile model rats from control.It indicated on relative analysis that relativity between ABRT value ascent and MDA ascent showed positive, relativities between ABRT value ascent and activity descents of SOD, NOS and iNOS showed all negative.It differently resisted ABRT value ascent and MDA ascent in cochlear tissues that senile model rats separately administered the alcoholic extract from 2.16, 4.32 or 8.64g·kg -1·d -1 PH[JP3]PH whose relativities between quantity and efficiecy showed all negative.It differently inhibited activity descents of SOD, NOS and iNOS in cochlear tissues that senile model rats separately administered various doses of EPHPH whose relativities between quantity and efficiecy showed all positive.Conclusion:EPHPH may relieve the degree of aged deafness and its mechanism may be connected with eliminating oxyen free radicals and increasing the activities of SOD, NOS and iNOS in cochleae of natural senile rats.[JP]
【Fund】: 甘肃省科学事业科研项目(No:QS041C3320)
【CateGory Index】: R285
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【Co-references】
Chinese Journal Full-text Database 2 Hits
1 GE Sheng-lei,ZHU Gang-hua,XIE Ding-hua(Department of Otolaryngology,the Second Xiangya Hospital,Central South University,Changsha 410011);Effect of Catechin on the Oxygen Free Radical in Cochlea of Aging Rats[J];Journal of Clinical Research;2007-08
2 PENG Bing,ZHOU Yuan,XIE Ding-Hua(Second Xiangya Hospital,Central South University,Changsha,Hunan,410011,China);Changes of SOD and MDA in auditory cortex,cochlear nuclei and cochlea of Wistar rats with age-related hearing impairment[J];Journal of Traditional Chinese Medicine University of Hunan;2008-01
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