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《Journal of Clinical Otorhinolaryngology》 2006-02
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The significance and effect of substance P on the expression of RANTES mRNA in allergic rhinitis

ZHANG Ruxin LIU Guojun WEN Wu YAN Zhiqiang WU Geping(Department of Otolaryngology,Changhai Hospital,Second Military Medical University,Shanghai,200433,China)  
Objective:To study the significance and effect of SP on the expression of RANTES mRNA in allergic rhinitis(AR),and deeply understand the pathogenesis of AR.Method:The model of AR was established in randomly selected healthy guinea pigs by using ovalbumin.Then the nasal dripping of SP was used to challenge the AR groups,as compared with the normal controls,in observation of the symptoms and histopathologic changes in the nasal mucosa.The number of eosinophil in the nasal lavage fluid was also counted.By means of RT-PCR,the expressions of RANTES mRNA in the nasal mucosa of the different groups were quantitatively compared.Result:SP challenge induced similar AR symptoms in the normal group and aggravated AR symptoms and inflammation in the nasal mucosa in the model of AR groups.The expression level of RANTES mRNA(P0.05) and the number of eosinophil(P0.01) in AR groups increased significantly after challenged with SP.Conclusion:In the pathogenesis of AR,SP induces the expression of chemokine RANTES in nasal mucosa,promotes eosinophil chemotaxis and migration,induces and aggravates the allergic inflammatory reaction in AR.
【Fund】: 国家自然科学基金资助项目(No:30271406);; 上海市卫生系统百名跨世纪优秀学科带头人培养基金资助项目(No:98BR003)
【CateGory Index】: R765.21
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