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《Journal of Clinical Otorhinolaryngology》 2006-07
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The effect of botulinum A toxin repeated injection in treating blepharospasm and hemifacial spasm

WANG Jinling ZHANG Xu(Department of Otorhinolaryngology,Xijing Hospital,Fourth Military Medical University,Xi'an,710032,China)  
Objective:To study the long-term efficacy of botulinum A toxin(BTXA) repeated injection for the treatment of blepharospasm and hemifacial spasm(HFS).Method:Eighty patients with blepharospasm and/or HFS(75 sides and 65 sides respectively) were treated with constant BTXA local repeated injection over 4 times and the dosage was 12.5~15.0U and 22.5~32.5U respctively in each injection.A total number of 886 injections were given.All the patients were followed up for 2~8 years.Result:The earliest effect was found in 2~3 days after the treatment.The effective ratios of the partial relieved,remarkably relieved and completely relieved in blepharospasm and HFS were 0,67.7%,32.7% and 1.4%,72.3%,26.3% respectively.The average duration of improvement lasted about(19.9±4.5) weeks and(20.7±4.2) weeks respectively(P0.05),which increased with the times of injection.The local side effects were mild and transient.Conclusion:BTXA for the treatment of blepharospasm and HFS is a safe,effective and simple method.
【CateGory Index】: R745.12
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