Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical Otorhinolaryngology》 2006-07
Add to Favorite Get Latest Update

Effects of prenatal alcohol exposure on auditory brainstem response in rats

LIU Yinghui LIANG Yong(Department of Otorhinolaryngology,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China)  
Objective:To study the effects of prenatal alcohol exposure,with an animal model of auditory brainstem response recorded in the conditions of various alcohol dosages administrated during embryonic period,on auditory nervous system in rats.Method:Normal female rats were divided into 2 groups.From the days 8.5 after mating,pregnant rats were fed 50% analytical reagent alcohol via intragastric administration with 2.0 and 1.0 g/(kg·d) respectively in consecutive 6 days.On the days 40 after birth,ABR was recorded in young rats under anesthesia.Normal young rats with parallel age were chosen as the normal group.Result:Prenatal alcohol exposure had effects on ABR,manifesting the incidence rate of I wave lowing(14%、30%),latency delaying(P0.05) and amplitude reducing.Conclusion:Prenatal alcohol exposure had conspicuous effects on auditory nervous system in rats,by step down nerve impulse conduction.
【Fund】: 广东省自然科学基金资助项目(No:032853)
【CateGory Index】: R764
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved