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《Journal of Clinical Otorhinolaryngology》 2006-07
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Effects of asphyxia on endocochlear direct-current potential in guinea pig

LIU Xiuli~1 REN Zhong~1 L Mei~2 Tsutomu Nakashima~3(~1Department of Otolaryngology,the First Affiliated Hospital of China Medical University,Shenyang,110001,China;~2Department of Otolaryngology,the First Affiliated Hospital of Dalian Medical University;~3Department of Otorhinolaryngology,Nagoya University Graduate School of Medicine)  
Objective:To investigate the mechanism of auditory function disturbance due to asphyxiants.Method:Guinea pigs with nice auricle reflex were selected in the experiment.The changes of endocochlear direct-current potential(EP) were detected when apnea and after artificial respiration,using the stria vascularis method.Result:①The original EP of experimental group wa(76.4±8.4)mV,and the original EP of control group was((80.8±)(8.4))mV,there was no significant different between them.②During apnea,the EP of all the guinea pigs decreased precipitously after incubation period of 8 to 34 seconds.The decreasing rate of EP was positively correlated to the incubation period(P=0.008).③After 3 minutes of apnea,the mean minimum of EP was(-17.5±4.4)mV,which was positively correlated with decreasing rate and incubation period(P was 0.000 2,0.000 separately).④After artificial respiration,it needed the average time of(85.0±16.0)s to return original EP,and 7 cases got an overrun.Conclusion:The EP of all the guinea pigs decreased when apnea,which showed the abnormal living circumstance of acoustic hair cells.After 3 minutes of apnea,the EP of all the guinea pigs decreased to negative value,which demonstrated that the functions of acoustic hair cells had not lost within 3 minutes of apnea.After artificial respiration,all the guinea pigs' EP returned to original value,witch indicated that the functions of the stria vascularis had not failed irreversible.
【CateGory Index】: R764
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