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《Journal of Clinical Otorhinolaryngology》 2006-13
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Effect of nitric oxide and nitric oxide synthase on sensorineural hearing loss secondary to secretory otitis media

CHEN Feng SHE Wandong DAI Yanhong SHEN Xiaohui QIAN Xiaoyun JIANG Ping GAO Xia (Department of Otolaryngology,Drum Tower Hospital,Affiliated to Nanjing University Medical College,Nanjing,210008,China)  
Objective:To evaluate the effect of nitric oxide synthase(NOS) and nitric oxide(NO) on sensorineural hearing loss(SNHL) secondary to secretory otitis media(SOM).Method:Samples of middle ear effusion were collected at the time of tympanocentesis from 16 cases of SOM with SNHL(group A) and 16 cases of SOM without SNHL(group B). And the concentration of NO and NOS activity in middle ear effusion were detected by colorimetric assay (Griess method).Result:The concentration of NO in group A(181.19±44.31)μmol/L was significantly higher than that in group B(137.00±40.67)μmol/L(P0.01).The NOS activity in group A(97.69±29.62)U was also significantly higher than that in group B(75.50±26.99)U(P0.05).Conclusion:Excess generation of NO in middle ear effusion which synthesized by NOS may hurt inner ear directly by its cytotoxic action or enhance local inflammatory reaction with other inflammatory factors.This study suggests that NO play a significant role in the process and pathogenesis of SNHL secondary to SOM.
【Fund】: 南京市科技局人才项目(No:20028054)
【CateGory Index】: R764.21
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