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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2008-01
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Relationship between fibrinogen level and pathogenesis of sudden sensorineural hearing loss

LU Liangjun1 ZHONG Zhisheng1 YU Yinkun2 DU Xiaodong3 GU Ping1WU Jun1 WANG Xu1 ZHOU Shufang1 GU Xiaochun1(1Department of Otolaryngology-Head and Neck Surgery,Haian Hospital of Nantong University,Haian,226600,China;2Clinical Examination Centre,Haian Hospital of Nantong University;3 Department of Otolaryngology-Head and Neck Surgery,Fourth Hospital of Suzhou University)  
Objective:To study the relationship between fibrinogen level and pathogenesis of sudden sensorineural hearing loss(SSHL).Method:Fifty patients(55 ears) with SSHL within 7 days of the onset were studied:a control group was consist of 50 normal-hearing people who were individually matched on a pairwise basis according to the same gender and age.Both the patients and the normal people were tested for the parameters of hemorheology,blood biochemistry,whole blood cell count and clotting function.Result:Fibrinogen level and plasma viscosity in patients with SSHL were significantly higher than that in control subjects.Prothombin time and activated partial thromboplastic time were significantly less in the patients group than that in the control group(P0.05).There were statistical difference.The parameters of blood biochemistry,whole blood cell count and platelet adhesion test of two groups had no significant difference(P0.05).Conclusion:Elevated plasma fibrinogen may be a major pathogenesis of SSHL.An increase in plasma fibrinogen level may lead to elevated plasma viscosity.All these may promote a prothrombic or hypercoagulable state and impair blood perfusion of cochlea.
【CateGory Index】: R764.43
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【References】
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1 MA Jing,HE Jun-ling,ZHOU Liu-qing(Department of Otorhinolaryngology,Lanzhou Military General Hospital,Lanzhou 730050,China);Effect of fibrinogenase on sudden hearing loss[J];Journal of Otolaryngology and Ophthalmology of Shandong University;2008-06
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1 WANG Mingshan1 WANG Xiaoxia1 CHEN Xiaodong1 CHEN Jianfu2 (1Department of Laboratory Medicine,First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000; 2Department of Otolaryngology,First Affiliated Hospital of Wenzhou Medical College);Study on the coagulation state of sudden deafness[J];JOURNAL OF CLINICAL OTORHINOLARYNGOLOGY;2000-07
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【Secondary References】
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1 YU Yuejin1 LU Zhicheng2 ZHANG Hongwen1 CAO Yunhong1 JIA Xiuhua1 HUANG Wei1 HAO Yanan1(1Department of Otorhinolaryngology,Shanghai No.7 People's Hospital,Shanghai,200137,China;2 Department of Laboratory Medicine,Shanghai No.7 People's Hospital);Association between anti-endothelial cell antibody and response to dexamethasone in sudden hearing loss[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2011-04
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