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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2008-01
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In vitro and in vivo biodegradation of sustained-release vehicle poloxamer 407 in situ gel

FENG Hongyun SUN Jianjun JIANG Ping(Center of Otolaryngology,People's Liberation Army,Naval General Hospital,Beijing,100037,China)  
Objective:To observe the biodegradation of poloxamer 407 gel in acoustic capsule in vitro and in vivo,and to explore the applied perspective in the local drug delayed-release treatment for inner ear disorders.Method:Weighing the remained amount of poloxamer 407 gel at 37℃ at fixation time interval.The right ears of 15 healthy guinea pigs as experimental group were perfused with 20% poloxamer 407 solution 100 μl in round window niche,the left ears as control group with normal saline.The histology of bullea at 7,14,28,49 days after perfusion was examined by means of serial section after paraffin imbedding.Result:The degraded amount were 20% and 25% in two groups respevtively.The poloxamer 407 gel at 37℃ after 7 weeks was(78.89±13.10) μg and(75.32±8.94) μg respectively.The poloxamer gel in bullea was almost biodegraded and discharged 49 days after perfusion,only few gel remained in the middle ear cavity under light microscope.The morphology of the mucosa of middle ear cavity and round window membrane were not significantly damaged after poloxamer 407 perfusion.Conclusion:Poloxamer 407 biodegraded slowly,but it could be biodigraded in vivo or discharged via eustachian tube,and caused no inflammation and immunologic rejection on the middler ear cavity.Thus,poloxamer 407 gel is suitable for the short-time sustained-release medical treatment in the inner ear diseases.
【CateGory Index】: R764.3
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【Co-citations】
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1 Gu Zhimin,Yang Jun,Wu Hao(Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,200092,China);Study the Pharmacokinetics of Dexamethasone in the Perilymph after the Sodium Alginate Dexamethasone Gel Transtympanic Administration in Vivo[J];听力学及言语疾病杂志;2008-01
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2 Yao-wen WANG1, Ji-hao REN2, Yong-de LU2, Tuan-fang YIN2, Ding-hua XIE2 (1Otolaryngology-Head and Neck Surgery Department, Ningbo First Hospital, Ningbo 315000, China) (2Otolaryngology-Head and Neck Surgery Department, the Second Xiangya Hospital, Central South University, Changsha 410001, China);Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss[J];Journal of Zhejiang University-Science B(Biomedicine & Biotechnology);2012-03
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1 Cao Qiang, Mao Tianqiu, Gu Xiaoming, et al. Department of Oral and Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University, Xi'an 710032;Injectable tissue-engineered bone using calcium alginate as carriers[J];实用口腔医学杂志;2003-02
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