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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2008-21
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The relationship between spontaneous apoptosis and radiation-induced apoptosis of laryngeal carcinoma

XIN Weihong1 YAO Ping1 JIANG Defu2 NI Jinsong3CHEN Qianqian1 WANG Jun1 KAN Yingnan1(1Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130031,China;2Department of Radiotherapy, China-Japan Union Hospital of Jilin University;3Laboratory of Pathobiology, Bethune Medical College of Jilin University)  
Objective:To study the change of laryngeal carcinoma cell apoptosis before and after radiotherapy.Method:Living tissue of diseased region obtained from 27 cases of laryngeal carcinoma before and during radiotherapy 10、30 and 60 Gy were used in this study. With terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling (TUNEL), the spontaneous and radiation-induced apoptotic rate (AR)were examined. Result:The AR of living tissue of laryngeal carcinoma before and during radiotherapy 10,30 and 60 Gy were (21.0±0.7)% , (60.0±1.5)%,(42.0±1.3)%,(25.0±1.9)%, respectively . The radiation-induced apoptotic rate was significantly higher than that of spontaneous apoptotic rate (P0.05). In laryngeal carcinoma, spontaneous apoptosis was positively correlated with the radiation-induced apoptosis. Conclusion:Detecting of AR of laryngeal carcinoma cells before and during radiotherapy may be helpful to predict the sensitivity of radiotherapy in laryngeal carcinoma patients.
【Fund】: 长春市科委资助项目(No:04-07SF046)
【CateGory Index】: R739.63
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Yang Huai'an ; Hozanwa Koji; Takasaka Tomonorr(Department of Otorhinolaryngology,the 1st Affiliated Hospital,China Medical University, Shenyang, 110001 );Relationship between p53 gene expression and radiation effect in laryngeal carcinoma[J];JOURNAL OF CLINICAL OTORHINOLARYNGOLOGY;1998-01
2 Chen Kiaowei; Wang Zhizhong; Zhang Lianshan; Peking Union Medical College Hospi-tal, Beijing 100730;Induction of apoptosis by expression of retroviral mediated wild type p53 gene in laryngocarcinoma cell line[J];Chinese Journal of Otorhinolaryngology;1996-03
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 QU Yan-li1,GU Fei2,LI Guang21.Department of Radiotherapy Ⅲ,Liaoning Tumor Hospital,Shenyang 110042,P.R.China2.Department of Radiotherapy,First Affiliated Hospital of China Medical University,Shenyang 110001,P.R.China;Radiosensitization effect of resveratrol on nasopharyngeal carcinorma CNE-1 cell in vitro[J];Chinese Journal of Cancer Prevention and Treatment;2009-22
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