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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2008-21
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Effect of Apoptosis of Vesicular Stomatitis Virus on Tumor Cells of Nasopharyngeal Carcinoma in vivo

FENG Yong1 HE Gang1 WU Yang2 WEN Yanjun2(1Department of Otorhinolaryngology, Peopleo's Hospital of Sichuan, Chengdu, 610072, China;2State Key Laboratory of Biotherapy of Human Diseases, West China Hospital, Sichuan University)  
Objective:To investigate apoptosis induced by vesicular stomatitis virus (VSV) in HNE-1 cancer cells of human nasopharyngeal carcinoma by models of nude mice-BALB/c in vivo. Method:HNE-1 cells are collected from culture bottle and injected infra right-side post-back epithelium of nude mice-BALB/c(6×106 cells/0.1 ml/each mice) to creat HNE-1 tumor models of nude mice-BALB/c. When the diameter of HNE-1 tumors is 5 to 8 millimeter, HNE-1 tumor models are treated with VSV (1×108 pfu /ml) or Saline. By Hoechst 33258-staining under fluorescence microscope, induction of apoptosis by VSV in HNE-1 tumor models are recorded and studied, compared with that by Saline in HNE-1 tumor models in vivo.Result: Compared with control group of saline , apoptosis of HNE-1 cancer cells of human nasopharyngeal carcinoma increase apparently in the remaining tumor cells of nude mice treated by VSV (P0.01).Conclusion:The present study suggests that the treatment with VSV could augment the apoptosis cells of human nasopharyngeal carcinoma in vivo.
【CateGory Index】: R739.63
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