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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2011-01
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The expression and clinical pathological significance of PDCD in laryngocarcinoma

FENG Guofei1 LI Peihua2 YOU Huihua1 LIU Wen2 ZHANG Xu2XU Xuegu2 SUN Guangming2 LI Fengchao3(1Department of Otolaryngology,the Central Hospital of Jinhua,Jinhua,321000,China;2Department of Otolaryngology,the Affiliated Hospital of Xuzhou Medical College;3Department of Pathology,the Affiliated Hospital of Xuzhou Medical College)  
Objective:To investigate the expression and clinical pathological significance of PDCD4 in laryngocarcinoma tissue and its potential significance to clinic.Method:Western-blotting and immunohistochemistry analyse to measure the protein expression of PDCD4 in 54 cases of laryngocarcinoma tissues(studying group) and their paraneoplastic normal tissues (control group). The correlations of PDCD4 with clinical pathological parameters were analyzed.Result:PDCD4 protein was positively expressed in paraneoplastic normal tissue while which was lost or decreased in laryngocarcinoma tissue by Western blot and immunohistochemistry. Immunohistochemistry assay showed the location of PDCD4 protein in cells was different between the studying group and the control group. The expression level of PDCD4 was related to the pathological grades of the laryngocarcinoma. It's higher in the well-differentiated tumor group than that in the poorly differentiated ones. But the expressions of PDCD4 were no differences among other clinical parameters including sex, age, clinical classification, clinical stage and the cervical lymphonodes who had been metastased or not.Conclusion:PDCD4 gene is anti-oncogene. It may play an important role in the pathogenesis and development of laryngeal carcinoma and it may be a new target of therapy for laryngocarcinoma.
【CateGory Index】: R739.65
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