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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2011-04
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Association between anti-endothelial cell antibody and response to dexamethasone in sudden hearing loss

YU Yuejin1 LU Zhicheng2 ZHANG Hongwen1 CAO Yunhong1 JIA Xiuhua1 HUANG Wei1 HAO Yanan1(1Department of Otorhinolaryngology,Shanghai No.7 People's Hospital,Shanghai,200137,China;2 Department of Laboratory Medicine,Shanghai No.7 People's Hospital)  
Objective:To investigate relationship between anti-endothelial cell antibody(AECA) and response to dexamethasone in sudden hearing loss(SHL).Method:Forty-eight SHL patients and thirtynormal controls with SHL were recruited in present study.AECA was detected by ELISA in serum of all normal controls and SHL patients as well as pure-tone average was examined by electronic audiometry during treatmentin SHL patients.Both AECA-positive and-negative subjects received 10 mg/d venous dexamethasone for 5 days followed by gradual tapering of dose of 5 mg/d for another 5-day.Then pure-tone average was reexamined.Differences in hearing recovery between AECA-positive and-negative subjects and relationship between AECA level and hearing recovery were analyzed.Result:The prevalence of AECA detection was 68.75%(33 of 48 patients) in SHL patients,with significant difference compared with control subjects with 23.33%(7 of 30 controls)(P0.01).After treatment,rates of response to dexamethasone in AECA-positive and-negative SHL patients were 81.8%(27 of 33 patients) and 33.3%(5 of 15 patients),respectively.Meanwhile,there was a significant difference in cure,excellent recovery,partly recovery and invalid between AECA-positive and-negative groups [(21.2%(7/33),33.3%(11/33),27.3%(9/33) and 18.2%(6/33) versus 0,13.3%(2/15),20.0%(3/15) and 66.7%(10/15),P0.01].Except 5 subjects with AECA level more than 263 μg/L,hearing recovery was correlated to pretreatment AECA level(r=0.808 4,P0.01).Conclusion:In sudden HL patients treated with dexamethasone,AECA might represent a serological marker of prognosis.
【Fund】: 上海市浦东新区社发局青年基金(No:PW2008B-5)
【CateGory Index】: R764.43
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 SUN Xialing REN Jihao LU Yongde YIN TuanfangWU Weijing TANG Yueying HU Binya(Department of Otolaryngology,the Second Hospital of Xiangya Medical College,Central South University,Changsha, 410011,China );Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2007-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIANG Xuefan1),SU Lizhong1),WANG Junbo2).1)Department of Otolaryngology,Zhejiang Provincial People's Hospital,Hangzhou 310014,Zhejiang;2)Department of Clinical Medicine,School of Medical & Life Sciences,Zhejiang University City College;The curative effect observation of dexamethasone on sudden deafness[J];Clinical Medicine;2008-02
2 JIANG Xuefan1),WANG Junbo2),SU Lizhong1).1)Department of Otolaryngology,Zhejiang Provincial People's Hospital,Hangzhou 310014,Zhejiang;2)Department of Clinical Medicine,School of Medical & Life Sciences,Zhejiang University City College;The curative effect observation of hyperbaric oxygen on sudden deafness[J];Clinical Medicine;2008-03
3 FENG Wenjing1,LIU Bo2,PENG Xiaoxia3, LIAN Nengjing2, NIU Leifang2(1 2005 post-graduate student, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China; 2 Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing Institute of Otolaryngology, Beijing, 100005, China; 3 Department of Epidemiology and Health Statistics, School of Public Health and FamilyMedicine, Capital Medical University, Beijing, 100069, China);The study of risk factors of sudden hearing loss[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2008-06
4 JI Qing~1 LIU Ying~1 WANG Yuan~2 WANG Qi~3 1 Department of Otolaryngology,th e Hospital of Tsinghua University,Beijing,100084,China; 2 Department of Otolaryngology,the General Hospital of China Aerospace Science and Technology Corporation,Beijing,100076,China; 3 Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing,100730,China;Clinical analysis of idiopathic sudden sensorineural hearing loss[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2008-07
5 Shao Jun,Guo Guang-wei,Su Ji-ping(Department of Otolaryngology and Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Methylprednisolone of Intratympanic Injection for Refractory Sudden Sensorineural Hearing Loss[J];Guangxi Medical Journal;2009-06
6 LING Ning,YANG Ying,LI Shanhong(Department of Otolaryngology,Affiliated Hospital of Qinghai University,Xining,Qinghai,810001,China);The observation on risk factors of the sudden sensorineural hearing loss in Qinghai[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2010-07
7 ZHANG Hongqing1,LIN Cheng2,LANG Juntian2,FAN Jingping2 (1 Department of Otolaryngology,the Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,Zhejiang,310009,China; 2 Department of Otolaryngology,Changzheng Hospital,the Second Military Medical University,Shanghai,200003,China);Evaluation of papers on vertigo studies in China[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2010-09
8 TANG Junxiang1,LIU Bo2,3,CHEN Xiuwu2,3,DUAN Jinping2,ZHAO Xiaoyan2,3,ZUO Lijing1(1 Capital Medical University,Beijing,100069,China;2 Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing,100730,China;3 Beijing Institute of Otolaryngology,Beijing,100005,China);The clinical characteristics of idiopathic sudden sensorineural hearing loss with vertigo[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2010-10
9 YE Fanglei,SHUAI Hua,ZHANG Gaixia(Department of Otolaryngology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,450000,China);Correlation factors influence prognosis of sudden deafness[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2010-10
10 YU Jian-min,SUN Yu-rui,ZHANG Yan-ping,ZHANG Shu-xin,HE Yun,GENG Ji-lu(Out-Patient-Department,the 309th Hospital of PLA,Beijing 100091,China);Clinical Investigation on Effects of Lipo-Prostaglandin E1 Combined with Hyperbaric Oxygen Therapy in 96 Patients with Sudden Deafness and Tinnitus[J];Clinical Misdiagnosis & Mistherapy;2010-04
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 LU Yongde REN Jihao WU Weijing YIN Tuanfang YANG Xinming XIE Dinghua (Department of Otorhinolaryngology, the Second Hospital of Xiangya Medical College,Central South University,Changsha, 410011,China);Intratympanic dexamethasone injections for intractable Meniere's disease[J];Journal of Clinical Otorhinolaryngology;2004-07
2 LU Yongde REN Jihao WU Weijing YIN Tuanfang TANG Yueying XIE Dinghua (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone for sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-01
3 REN Jihao LU Yongde YIN Tuanfang LIU Bin GE Yilin (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone injections for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-05
4 LU Liangjun1 ZHONG Zhisheng1 YU Yinkun2 DU Xiaodong3 GU Ping1WU Jun1 WANG Xu1 ZHOU Shufang1 GU Xiaochun1(1Department of Otolaryngology-Head and Neck Surgery,Haian Hospital of Nantong University,Haian,226600,China;2Clinical Examination Centre,Haian Hospital of Nantong University;3 Department of Otolaryngology-Head and Neck Surgery,Fourth Hospital of Suzhou University);Relationship between fibrinogen level and pathogenesis of sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-01
5 NIE Guo-hui, LU Yong-de. Department of Otorhinolaryngology, Second People′s Hospital of Shenzhen, Shenzhen 518035, China;Curative effect of transtympanic perfusion of gentamicin on unilateral Ménière's disease[J];National Medical Journal of China;2003-15
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