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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2011-07
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A clinical analysis of 33 cases of Kimura′s disease

LIU Shengwen1 HUANG Lulu1 ZHANG Zhen′gang1 KE Changshu2 QI Junying1(1Department of Infection,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China;2Department of Pathology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology)  
Objective:To improve the diagnosis and treatment of Kimura′s disease(KD) by investigating its clinical characteristics,pathological features and complications.Method:The clinical data of 33 cases of KD were analyzed retrospectively.Result:Of 33 cases,22 showed the mass on head and neck,while in the other cases,the mass distributed in the region of groin,axillary fossa,hilum of lung and mesentery.Regional lymph nodes were involved in 21 cases and major salivary glands were invaded in 8 cases.Twenty-three cases had typical peripheral eosinophilia,although only in 2 patients the quantity of serum total IgE increased markedly.Urine abnormalities happened to 7 cases,such as massive proteinuria(3 cases) and hematuria(2 cases).Among 6 cases which underwent bone marrow aspiration,2 showed eosinophilia.Two cases were complicated with nephritic syndrome.Six cases were combined with local inflammation on head and neck and 2 cases were combined with malignant tumor.Conclusion:Mass on the head and neck is the typical clinical manifestation in KD,with regional lymph nodes and major salivary glands involved most.Serum total IgE and histopathologic examination should always be done to confirm KD,especially in the cases with unknown eosinophilia increasing.
【CateGory Index】: R597
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