Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Effects of Honokiol on proliferation,migration and invasion in nasopharyngeal carcinoma cells

QU Li;ZHANG Rui;Department of Otolaryngology,Nanyang Central Hospital;  
Objective:To investigate the effects of Honokiol on proliferation,migration and invasion in nasopharyngeal carcinoma cell line CNE-1and to explore the possible mechanism.Method:Cell viability was assessed using MTT in CNE-1cells treated with different concentrations of Honokio(0,20,40,80 and 160μmol/L).Cell migration and invasion were analyzed by wound healing and Transwell assay.The protein expression of PTEN,p-Akt and p-mTOR were determined by Western Blot.Result:MTT assay showed that Honokiol decreased CNE-1cell viability in a concentration-dependent manner.The maximal inhibitory effects reached at 80μmol/L.The ability of CNE-1cell migration and invasion were significantly inhibited after Honokiol treatment.Moreover,western blotting revealed that Honokiol treatment resulted in an increase of PTEN protein expression and a decrease of pAkt and p-mTOR expression.Conclusion:Honokiol inhibits nasopharyngeal carcinoma cell line CNE-1proliferation,migration and invasion via inactivation of PTEN/PI3k/Akt signaling pathway.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved