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Analysis of tumor necrosis factor-α and zinc finger protein 36 gene polymorphism for patients with obstructive sleep apnea syndrome

WANG Lin;YAN Ni;XU Poshi;ZHU Youli;Department of Otolaryngology,Henan Province People's Hospital,Zhengzhou University People's Hospital;Department of Ophthalmology,Henan Province People's Hospital,Zhengzhou University People's Hospital;Department of Laboratory,Henan Province People's Hospital,Zhengzhou University People's Hospital;  
Objective:To investigate the association between obstructive sleep apnea hypopnea syndrome(OSAHS)and tumor necrosis factor(TNF)-αand zinc finger protein 36(ZFP36)gene polymorphisms.Method:Two hundred and four patients with OSAHS were enrolled as study group.Meanwhile,97 healthy subjects were selected as control group.Three sites of ZFP36gene(rs17879933,rs3746083 and rs251864)were detected by TaqManPCR method.The levels of TNF-αand other biochemical markers were detected by radioimmunoassay,and relevant indicators of breathing during sleep at night of all the subjects were recorded by Monet32 system.Result:The levels of TNF-α,total cholesterol,uric acid,diastolic blood pressure,systolic blood pressure,body mass index,abdominal circumference and neck circumference were significantly higher in the study group than those in the control group(all P0.05).The genotype and allele frequencies of rs251864 and rs17879933were significantly different between the study group and the control group(all P0.05).The levels of abdominal circumference,BMI,TNF-αand TG in patients with rs251864 GG and rs17879933 Ⅱ genotypes were significantly higher than those with the other two genotypes(all P0.05).There was no significant difference in all the sleep respiration indexes between the three genotypes of ZFP36(all P0.05).Logistic regression analysis showed that there was no correlation between three polymorphisms of ZFP36 and OSAHS after controlling a series of factors such as gender and age.Conclusion:ZFP36may be involved in the pathogenesis of OSAHS by modulating inflammatory factors such as TNF-αand interfering with metabolism.ZFP36 mutation at three sites is not an independent risk factor for OSAHS.
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