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The expression and role of PLUNC,TLR2 and NF-κB in nasal polyps

DING Nan;LI Chunmiao;BA Yunpeng;Department of Rhinology,the First Affiliated Hospital of Zhengzhou University;  
Objective:To investigate the expression of palate,lung,nasal epithelium clone(PLUNC),Tolllike receptor 2(TLR-2)and nuclear factor-Kappa B(NF-κB)in nasal polyps tissues and normal inferior turbinate mucosa.To analysethe correlation of their expression and to provide a new treatment of nasal polyps.Method:The specimens were divided into two groups:nasal polyps tissues group(n=46)and normal inferior turbinate mucosa group(n=19).EOS and others inflammatory cells was detected by HE staining.performing immunohistochemistry,we investigated the expression and distribution of PLUNC,TLR2 and NF-κB.Meanwhile we evaluated the positive expression and correlation of PLUNC,TLR2 and NF-κB between experimental group and control group.All data were processed by using SPSS 21.0software.Result:EOS infiltration was significantly higher than the control group(χ~2=12.01,P0.05).the expression level of PLUNC in experimental group is significantly lower,there is a statistical significance(χ~2=16.09,P0.05).The expression of TLR2 and NF-κB in experimental group is obviously higher than the control group,with statistical significance(χ~2=23.74,χ2=18.59,P0.05).Spearman correlation analysia showed that PLUNC in experimental group is negatively correlated with TLR2 and NF-κB(r=-0.675,r=-0.550,P0.05),TLR2 is positively correlated with NF-κB(r=0.540,P0.05).EOS infiltration degree positive correlation with TLR2 and NF-κB exist,(r=0.417,r=0.470,P0.05),degree negative correlation with PLUNC exist(r=-0.859,P0.05).Conclusion:PLUNC expression in nasal polyps is lower than the normal inferior turbinate group.TLR2 and NF-κB expression in nasal polyps are higher than the normal inferior turbinate group.suggesting that the formation of nasal nolyps may be associated with lower natural immunity and the existing of infectious agents.
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