Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical Pulmonary Medicine》 2005-01
Add to Favorite Get Latest Update

Assessement of liver function damage among HBVM-positive patientsas the result of chemical anti-tuberculosis treatment

JIANG Ruihua XU Jialian Department of Tuberculosis, Shanghai Pulmonary Hospital, Shanghai 200433, China  
Objective To assess the liver function damage among HBVM-positive patients as the result of anti-tuberculosis treatment and examine possible coping method. Methods A retrospective analysis of 691 inpatients was made. All the patients had positive mycobacterium tuberculosis as confirmed in their sputa examination.The rate of liver function damage in the HBVM-positive cases (Group B n=97) and in the HBVM-negative cases (Group B n=594) was compared. Results Seventy-three cases had liver function damage out of 691 (10.56%), 44 cases had liver function damage out of Gourp A (45.36%), as compared 29 cases in group B (4.88%): P 0.01. There were 546 cases who used RFP and 68 cases had liver function damage (12.45%), whereas 145 cases using RFT and 5 had liver function damage (3.45%): P 0.01. There were 88 HBVM positive cases who used RFP 44 had liver function damage (48.86%), whereas there were 458 HVBM negative cases using RFP and 25 had the damage (5.46%): P 0.01. There were 9 HBVM positive cases whose treatment plans had included RFT and 1 had the damage (11.1%): P 0.05. Conclusion Due to the use of anti-tuberculosis treatment, the HBVM positive patients obviously had increased their chances of damaging their liver function.The use of RFP seems to have caused more damage as compared to the use of RFT. It is thus recommended that for the HBVM positive patients RFT and other liver-less-damage drugs shouldbe used the treatment of tuberculosis for the protection of liver.
【CateGory Index】: R521;R512.6
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 HUANG Qing-hua;Assessement of liver damage among HBVM-positive patients as the result of anti-tuberculosis drug.[J];Journal of Jinggangshan Medical College;2005-04
2 LI Jin-sheng,WANG Fu-sheng,CHEN Yu Hospital for Chronic Diseases of Gaozhou of Guangdong Province,Gaozhou 525200,China;The impact of HBVM positive to hepatic function and relative countermeasure[J];Journal of Clinical Pulmonary Medicine;2009-05
3 XU Guang-hui, CHEN Zhi-yu,ZHEN Zhi-bin,et al.Jiangmen Institute of Tuberculosis Prevention and Control,Jiangmen 529000,China;Cohort Study on the Drug-induced Hepatitis of the Pulmonary Tuberculosis Patients Co-infected with Hepatitis B Virus[J];Medical Innovation of China;2013-22
Chinese Journal Full-text Database 10 Hits
1 DU Zheng-xin, LIU Gui-si (Guangzhou Municipal Chest Hospital,Guangzhou,Gangdong,510095,China);Influence of Different TB Chemical Treatment Schemes on Liver Function[J];Anhui Journal of Preventive Medicine;2003-05
2 LI Shui-qin1, LI Ping2, WANG Fei1, MA Hong-hao1, LI Guan-hong1, XIA Qiu-cheng1 (1Chengdu University of TCM, Chengdu 610075, China; 2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, Chnia);Proved cases of drug-induced severe liver damage treated by Professor LI Ping[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-08
3 Nie Yanfang Li Jihong (Datong No 4hospitai,post,037008)$$$$;Effect of antituberculesis drugs on liver functctions of the tuberculosis patient complicated with hepatitis is vivus infections[J];Journal of Datong Madical College;2006-02
4 MEI Mei,LU Wei.Department of Gastroenterology,Hehai Hospital,Tianjing 300350;Clinical curative effect of telbivudine in tuberculosis patients with hepatitis B viral carriers[J];Journal of Clinical Hepatology;2011-02
5 ZHU Jing-hui(Department of Pharmacy,The contagious Hospital of Changchun City,Jilin 130123,China);Application of Glutathione in Treatment of Hepatic Lesion Caused by Antituberculosis Drug[J];Heilongjiang Medical Journal;2005-12
6 ZHANG Hai,HAN Zhiqi,ZHU Zenghong,et al;Clinical Observation of Tiopronin in Treating Liver Injury Caused by Anti-Tuberculosis Drug[J];Journal of Medical Forum;2004-01
7 WANG Hui (Tumour and Antituberculosis Hospital of Heze Prefecture,Heze 274029,China);Observation and Nursing of Side Reaction of Digestive System by Rifampin[J];Journal of Heze Medical College;2000-04
8 MING Ping-liang,YIN Jun,LIU Xiao-rong,SUN Chun-mei,TANG Lan,WU Xu. (Department of Infectious Disease,Chinese People's Armed Police Forces 8730 Hospital,Guangzhou 510800,China);Effects of 2HRZS(E)/4HR regimen on the liver function of pulmonary tuberculosis patients with positive markers of viral hepatitis B[J];Chinese Journal of Infection and Chemotherapy;2008-05
9 Su Shou 5th people hospital,Jiang Su 215007 ZU SHU BAO.ZHANG JIAN PING$$$$;Effect of 2HRS(E)Z/4HR on the liver function of the pulmonary tuberculosis patients with positive markers of viral hepartitis B[J];Journal of Clinical Pulmonary Medicine;2002-04
10 Zhou Lin Xu Yu Huang Yongjun Chinese Center for Disease Control and Prevention National Center for Tuberculosis Control and Prevention Beijing Haidian Hospital and Beijing Chest HospitalBeijing 100050 China;The blood-fat metabolic disorder caused by and its effect on liver function[J];Journal of Clinical Pulmonary Medicine;2004-05
China Proceedings of conference Full-text Database 1 Hits
1 CHEN Si-cang CHEN Hong-qi.The peoples Hospitol of Pan' an county,Zhejian 322300;Obervation of the effect on liver function in pulmonay tuberculosis with positive HBVM treated by antituberculotic combination[A];[C];2004
Chinese Journal Full-text Database 10 Hits
1 PAN Yuejun,ZHANG Chunlan,FAN Huimin,et al. The Department of Liver Disease,Eighth People’s Hospital,Guangzhou,510060;The effect of antituberculosis drugs on the liver function in patients with hepatitis B[J];Journal of Clinical Hepatology;2008-03
2 L.de Castro,P.E.A.A.do Brasil,T.P.Monteiro,V.C.Rolla Instituto de Pesquisa Clinica Evandro Chagas,Fundao Oswaldo Cruz,Rio de Janeiro,Rio de Janeiro,Brazil;Can hepatitis B virus infection predict tuberculosis treatment liver toxicity? Development of a preliminary prediction rule[J];The International Journal of Tuberculosis and Lung Disease;2010-03
3 ZHANG Leping WANG Yuanhong Zhaoqing Pulmonary Hospital of Guangdong, province, Zhaoqing, 526020, China;Effect of protecting liver function on treating pulmonary TB patients with HbsAg positive[J];Journal of Clinical Pulmonary Medicine;2005-04
4 Tao Honghui, Lin Yan(Department of Pharmaceutics, Shanghai Huangpu District Central Hospital, Shanghai,200002);Clinical analysis of drug-induced liver injury[J];Shanghai Medical & Pharmaceutical Journal;2004-06
5 Xu Guanghui~1,Chen Weiqing~2,Chen Hua~1,Tang Zhiqiang~1,Wen Li~1 1.Tuberculosis Prevention and Control Institute of Jiangmen,Jiangmen 529000,Guangdong,China; 2 Department of Medical Statistics and Epidemiology,School of Public Health,Sun Yat-sen University;Influence Factors of Liver Injury Induced by Anti-tuberculosis Drugs[J];Chinese Journal of Pharmacoepidemiology;2008-06
6 Zha Yuefang,Zeng Wen,Hu Jianjun,et al.Department of Respiratory Tubercularsis Chest Hospital,Shi jiazhuang 050041,China;Study on the hepatoxicity induced by antitubercular medicines in rat models[J];The Journal of the Chinese Antituberculosis Association;2006-03
7 Chen Zhifei,Han Dan,Sun XuezhiWuhan Antituberculosis Hospital,Wuhan 430030,China;The relationship between HBsAg carrier state and hepatotoxicity during anti-tuberculosis chemotherapy[J];The Journal of the Chinese Antituberculosis Association;2007-04
8 Xing Tongjing, Chen Jiabao, Zhang Guangshu, et al. The 88th Hospital of PLA, Taian 271000;Clinical and pathological analysis of liver injury resulting from rifampin and isoniazid[J];CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES;1997-01
9 Xiao Qing-hua, Deng Ze-zheng, Liu Jian-xiang, Mao Chang-geng and Li Qing-an (The 163th Hospital of PLA, Changsha 410003);Risk factor analysis of hepatic toxicity of antituberculosis agents[J];Chinese Journal of Antibiotics;2004-12
10 GUO Hong,LI Huan,LI Shu-fen,YAN Hui-yi(Medical College of Beihua University,Jilin 132013,China);On Mechanism and Factor of Liver Dysfunction by Anti-tuberculosis Drugs[J];Journal of Beihua University(Natural Science);2006-02
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 DUANMU He-yun,CAO Hui-juan Department of Respiration,Changzhou 3rd Hospital,Changzhou,Jiangsu Province 213001,P.R.China;Clinical study on Lamivudine in treatment of hepatitis B combined with antituberculosis-induced hepatic lesion[J];Journal of Clinical Pulmonary Medicine;2012-03
2 ZHAO Dong, LI Hong-lu, DIAO Zhenying, LI Chang-qing. Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;Clinical features of 141 patients with drug-induced hepatitis[J];Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition);2013-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Xu Feng;ChenHuilan;Yan Bin.et al.(Huangshi Municipal Infec-tious Diseases Hospital,Huangshi 435000);The detection and significance of HBV-DNA in serumof pulmonary tuberculous patients[J];CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES;1995-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved