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《Journal of Clinical Pulmonary Medicine》 2005-01
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Assessement of liver function damage among HBVM-positive patientsas the result of chemical anti-tuberculosis treatment

JIANG Ruihua XU Jialian Department of Tuberculosis, Shanghai Pulmonary Hospital, Shanghai 200433, China  
Objective To assess the liver function damage among HBVM-positive patients as the result of anti-tuberculosis treatment and examine possible coping method. Methods A retrospective analysis of 691 inpatients was made. All the patients had positive mycobacterium tuberculosis as confirmed in their sputa examination.The rate of liver function damage in the HBVM-positive cases (Group B n=97) and in the HBVM-negative cases (Group B n=594) was compared. Results Seventy-three cases had liver function damage out of 691 (10.56%), 44 cases had liver function damage out of Gourp A (45.36%), as compared 29 cases in group B (4.88%): P 0.01. There were 546 cases who used RFP and 68 cases had liver function damage (12.45%), whereas 145 cases using RFT and 5 had liver function damage (3.45%): P 0.01. There were 88 HBVM positive cases who used RFP 44 had liver function damage (48.86%), whereas there were 458 HVBM negative cases using RFP and 25 had the damage (5.46%): P 0.01. There were 9 HBVM positive cases whose treatment plans had included RFT and 1 had the damage (11.1%): P 0.05. Conclusion Due to the use of anti-tuberculosis treatment, the HBVM positive patients obviously had increased their chances of damaging their liver function.The use of RFP seems to have caused more damage as compared to the use of RFT. It is thus recommended that for the HBVM positive patients RFT and other liver-less-damage drugs shouldbe used the treatment of tuberculosis for the protection of liver.
【CateGory Index】: R521;R512.6
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