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Coaggregation and coaggregation inhibition between perio-pathogenic and cariogenic bacteria

FU Rao, LI De-yi. Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011,China  
Objective:To screen the coaggragating pairs between perio-pathogenic and cariogenic bacteria and to investigate the susceptibility of these coaggregations to inhibitors.Method:4 strains of perio-pathogenic bacteria,Fusobacterium nuleatum(Fn)ATCC 10953, Actinobacilllus actinomycetem comitans (Aa)Y4, Porphyromonas gingivalis(Pg )ATCC 33277 and Prevotella intermedia (Pi)ATCC 25261 and 4 strains of cariogenic bacteria,Streptococcus mutans(Sm )Ingbritt,Streptococcus sanguis(Ss )34, Actinomyces viscosus(Av)19246 and Lactobacillus acidophilus(La)ATCC 4356 were used to determine the coaggregating degree of various combinations of the above bacteria by a visual assay and a turbidimetric assay. Then more than 2(or 20%) coaggregation degrees' pairs were used to investigate the inhibitory effect of lactose and arginine.Result: The coaggregation degrees of Fn-Av, Pg-Av, Fn-Sm, Fn-Ss, Fn-La and Pg-Ss pairs were higher than +2(or20%). 4.5 mM~6.0 mM of arginine were considerably effective to most of the above pairs and the disaggregation degrees are 49%~92%. 120 mM~300 mM of lactose were significantly effective to Pg-Ss pair, the disaggregation degrees are 57%~91%. However, they are almost ineffective to Fn-G + pairs and Pg-Av pair.Conclusion: The coaagregations between perio-pathogenic and cariogenic bacteria are specific. Most of them are relatively sensitive to arginine.
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