Itraconazole enhances the antifungal ability of soft lining materials

TAO Ren-chuan,DENG Hua-jie,HUANG Guang-wu.Stomatologial Hospital Affiliated to Guangxi Medical University,Nanning 530021,China  

Objective:Soft lining materials play an important role in clinical removable prosthodontics,which relieves the pressure transmitted by denture on mucosa.However,there is an increased probability of yeast colonization on soft lining materials,which is a causative factor in denture stomatitis.This study aimed to investigate the function of addition of Itraconazole into soft lining material for anti-candida adherence.Method:Four different types of soft lining materials were used in this study.Itraconazole was added into materials respectively by 3,6,9W/W drug/material ratio.Then making the mixed material into standard pieces for test the adherence of candida albican on the surface by culture,counting the cloning.Result:Among four kinds of materials,the pieces with itraconazole showed significantly stronger anti-fungal ability than the soft lining materials alone.The antifungal ability decreased within 6-8 days.No significantly difference observed between the 6%w/w and 9%w/w for the same material,however,both showed higher antifungal ability than samples with 3%itraconazole or with 0 % itraconazole.Conclusion:For any soft liner material,the inhibition ability to candida albican is associated with the concentration of itraconazole added;the reasonable effect can be achieved by 6% w/w,and decreased by time.It suggests that itraconazole may be added into soft lining material to prevent denture stomatitis in short time purpose.

【Fund】： 国家自然科学基金课题(30160087);; 广西青年科学基金项目(桂科青0144029)
【CateGory Index】： R783

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