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Detection of IFN-γand Interleukin-10 in gingival crevicular fluid from active and non-active adult periodontitis sites

MA Jing-zhi,Pang Ai-hui,Li Ming,Center of Stomatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China  
Objective:To reveal the relationship between IFN-γand IL-10 and the activity of periodontitis. Method: The concentration of IFN-γandIL-10 in gingival crevicular fluid(GCF) was measure by ELISA. Sixty teeth from 40 patients with adult periodontit is were sampled, among which there were 30 teeth in active phase, while the rest were in non-active phase.Result:Significant difference was found in the level of IFN-γ in GCF between the active group(14.25±2.35 ng/ml and the non-active group (4.36±0.41 ng/ml,P 0.05) and in the level of IL-10 in GCF between the active group(3.64 ±0.56 ng/ml) and the non-active group(11.26±3.05 ng/ml,P0.05). Conclusion:IFN-γ,the Th1 cytokine may be predominant in diseased sites, whereas IL-10,the Th2 cytokine may reduces local inflammation. The high ratio of IL-10/IFN-γ may be related to reduced clinical periodontal parameters.
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