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Changes of expressions of calcitonin Gene-Related Peptide in trigeminal ganglia with occlusal reconstruction for unilateral chew in rats

LI Xiao-guang,LIU-Min,YANG Xian-yong,WANG Yan-xiu. Department of Stomatology,Taian City Central Hospital, Shandong 271000, China  
Objective:Our aims were to study the expressions of Calcitonin Gene-Related Peptide (CGRP) in trigeminal ganglia(TG) with occlusal reconstruction for unilateral chew in rats,and to discuss the mechanism of temporomandibular disorders.Method:30 wistar male rats were randomly divided into 3 experimental groups and 3 control groups,5 rats in each group .The molar of right maxillary and mandibular of rats in experimental groups were ground to the gingival level without occlusal contact. The occlusal contact was recovered by stoping grounding molar of the rats.The section of trigeminal ganglia underwent the immunohistological study to evaluate the expressions of CGRP by using SABC method.Light microscope and microscoic photo analytic software and SPSS10.0 statistical software were used.Result: The percentage of CGRP positive neurons in TG with Unilateral Chew experimental group was significantly decreased compared with control group (P0.01,P0.05),The decreased extent in non-chewing side was much lower than that in the chewing side(P0.05).There was no significantly difference in the percentage of CGRP positive neurons between the early occlusal reconstruction experiment group and control group(P0.05) and there was no significantly difference between the non-chewing side and the chewing side(P0.05). There was significantly difference in the percentage of CGRP positive neurons between the later occlusal reconstruction experiment group and control group(P0.01,P0.05) and there was significantly difference between the non-chewing side and the chewing side(P0.05).Conclusion: The expressions of CGRP in TG can recover normal in the early occlusal reconstruction and that not in the later occlusal reconstruction.CGRP might participate in the histopathologic mechanism of temporomandibular disorders.
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