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The effects of neoadjuvant chemotherapy on survival rate and quality of life of the patients with oral squamous cell carcinoma

YANG Kai,LI Ya-dong,ZHANG Fu-jun,CHEN Rui,ZHANG Jin-song. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016,China.  
Objective:To investigate the effects of neoadjuvant chemotherapy(NACT) on survival rate and quality of life (QOL) of the patients with Oral squamous cell carcinoma (OSCC).Method:132 patients with T3 and T4 OSCC were divided randomly into two groups: groupⅠ(surgery) 75cases; groupⅡ(NACT+surgery) 57cases. 5-year survival rate of different groups were analyzed by SPSS10.0 statistic software, UW-QOL questionnaire was used to evaluate QOL of different groups.Result:①5-year survival rate of groupⅠand groupⅡ were 42.8﹪ and 55.8﹪respectively(P﹤0.05);5-year survival rate of the patients who was response to NACT and was non-response to NACT were 66.5﹪ and 45.9﹪respectively(P﹤0.05);5-year survival rate of the patients who was non-response to NACT and groupⅠ were 45.9﹪ and 42.8﹪respectively(P﹥0.05).②QOL of groupⅡwas significantly higher than that of groupⅠ(P﹤0.05); QOL of the patients who was response to NACT was significantly higher than that of the patients who was non-response to NACT(P0.05);QOL were no significant statistical difference between groupⅠand the patients who was non-response to NACT(P0.05).Conclusion:Effective neoadjuvant chemotherapy can improve survival rate and quality of life of the patients with Oral squamous cell carcinoma.
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