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The immunohistochemical study of β1-integrin in oral submucous fibrosis.

QUE Guo-ying,PENG Jie-ying,LI Feng-hua Department.of Stomatology of Xiangya Hospital ,Central South University ,Changsha 410008,China  
Objevtive:T0 study the localization of β1-integrin in Oral Submucous Fibrosis(OSF)and the relation betweenβ1-integrin and OSF.Method:Sensitive Immunohistochemical and morphometric technigue were adopted in examination of localization andcontent of β1-integrin in oral mucosa form 30 patients with OSF(10 for early.moderate and advanced stage respectedly),10 normal oral mucosa.Result:Study showed:(1) The overexpression of β1-integrin in mucosa from OSF,and the immunostains for β1-integrin were prominent within cytoplasm.and on the cell membrane of spinocells ,basiocells ,fibroblasts,vascular endothelial and smooth muscle cells;(2)There was a statistical difference in expression of β1-integrin among three stages;(3) There was little expression of β1-integrin immunostains in oral mocusa.Conclusion:β1-integrincould piay a role in the fibrogenic process of OSF.
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