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Influence of matrine on the adhesion of candida albicans to human buccal epithelial cells

WU Lan,ZHOUYong-mei,SHI Lin-jun,ZHOU Zeng-tong. Department of Oral Medicine,College of Stomatology,Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University.Shanghai Research Institute of Stomatology. Shanghai 200011,China  
Objective:To investigate the influence of different concentrations of matrine on the adhesion of candidaalbicans to human buccal epithelial cells. Method:C. albicans collection strain ATCC76615 was obtained and co-culturedwith human buccal epithelial cells after following brief exposure to different concentrations of matrine in vitro. The numbersof adherent C. albicans were counted in 50 human buccal epithelial cells(BEC)after Gram stain.Result:Compared with thedrug-free controls,C. albicans which were pretreated with matrine were seen have a significant reduction in adhension withBECs in vitro. C. albicans which were co-cultured with human BECs in vitro interfered by matrine demonstrated a decreasedadhension to BECs.Conclusion:Matrine could inhibit C. albicans adhesion to human BECs in vitro.
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