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The study on alteration of cytokeratins expression in OLP

JIAN Jie,NIE Min-hai,FENG Yan,GU Ya-lan.Af-filicated Dental Hospital of Luzhou Medical College,Shichuan 646000,China  
Objective:To explore the possible alteration of cytokeratins expression in OLP and reveal the nosogene-sis of OLP.Method:The expression of cytokeratins were detected in 15 samples of OLP by means of SDS-PAGE and Western blot.Result:In control group,we detected the appearance of cytokeratin1、2、4、5、11、13、14、16.There are cytoker-atin 1、11、13、14、16、17 in oral buccal mucosa of OLP lesions.Conclusion:①.OLP lesions demonstrated profound changes in the site-specific CK profile.The presence of CK1 in OLP lesions may due to a range of stimuli that put a heav-ier functional demand on the tissue.Thus,it can make epithelium thickening.②.The decreased expression of CK2、4、5 are respectively correlated with the abnormal keratinization,abnormal differentiation and necrotic alteration of the basal layer.
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