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Effects of cyclic-tension force on the expression of MMP-1 mRNA in HPDLF

ZHANG Xiao-dong,SONG Jiu-yu,LI Xiang,DONG Ji-jun,LI Yong-ming,LIN Zhu.Department of Stomatology,Shenyang Military General Hospital,Shenyang 110015,China.  
Objective:To investigate the effects of the mechanical strain on the expression of MMP-1 mRNA in HPDLF.Method:HPDLF were subjected to 12% elongation by stretching frequency 0.2Hz in this experiment.The expres-sion of MMP-1 mRNA was determined at 12 h,24 h,48 h by in situ hybridization(ISH)and RT-PCR.Result:The expres-sion of MMP-1 was positive in HPDLF cultured in vitro and increased in a time-dependent manner after loading cyclic-ten-sion force.Conclusion:The cyclic-tension force promoted the expression of MMP-1 in HPDLF,suggesting possibly impor-tant role of MMP-1 in the metabolism of ECM.
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