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Expression of biglycan and decorin in the developing pulpo-dentinal complex of postnatal mouse

TANG Kai-liang,LI Shu,JIANG Shu-ming,WANG Jian,GAO Yan,YU Lan.Department of Periodontology,School of Stomatology,Shandong University.Shandong Jinan 250012,China.  
Objective:To study the distribution and expression of decorin and biglycan in developing normal periodon-tal tissues,so as to understand its role in puplo-dentinal complex formation.Method:Thirty six BALB/c mice in different developing stages were killed and their bilateral mandibular first molars with surrounding alveolar bones and gingival tussues were taken out,Power VisionTM two steps immunohistochemical method with anti-decorin and anti-biglycan was used to de-tect the tissue distribution and cellular localization of decorin and biglycan.Result:At 5 day of age biglycan was strongly ex-pressed in predentin and odontoblasts.With the development of pulpo-dentinal complex,the reduction of expression in pre-dentin and odontoblasts was observed,But it gradually raised in pulp.Decorin was expressed in predentin,but negative in dentin and odontoblast.Biglycan and decorin were continually expressed throughout the period of investigation.Conclusion:It is proposed that decorin and biglycan accumulate at defined stages during dental tissue differentiation and development,they may play specific roles in cell-cell and cell-matrix interactions.
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