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The histology research of maxillary suture induced by sutural distraction osteogenesis in growing mongrel dogs

YAO Yu-sheng,LIU Chun-ming,CHANG Shi-min,JIN Zeng-qiang,WANG Gui-jun.Department of Stomatology Affiliated Second Hospital of Liaoning Medical College,Liaoning 121001,China  
Objective:To observe the response and changes of maxillary suture to distraction forces in growing mon-grel dogs.Method:21 mongrel dogs about 3~4 month were used in the study.A self-designed internal nickel-titanium shape memory metal was used for expanding maxillary suture.3 dogs were killed 5、10、15、20、30 and 40 days respectively after operation,the distracted suture samples were harvested and processed for transmission electron microscopic observation and immunohistochemistry examination of BMP-2、4、7 expression,other undistracted animals were used as the controls.Result:The transverse palatine suture was extened successfully in distracted dogs.Strong expression of BMP-2、4 were de-tected in the fibroblast-like cells and the active osteoblasts.However the expression of BMP-7 in low expression during os-teoblast distraction.Conclusion:The sutural distraction osteogenesis is a effective operative method to extend the maxillary bone of dogs in development stage.BMP-2、4 may play important roles in the process of bone formation during suture dis-traction osteogenesis.Distraction force of 1500 g not only can't damage osteoblast but also improve it's biologic activity.
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