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Effects of AGEs on the expression of MMP-3 and TIMP-1 by human periodontal ligament cells

WANG Wan-chun1,WU Ning2,CHEN Qing3.1.Qingdao Stomatology Hospital,Shandong Qingdao 266000,China;2.Department of Endocrinology,Qingdao Municiple Hospital,Shandong Qingdao 266071,China.  
Objective:To investigate the effects of the mechanical AGEs on the expression of MMP-3 and TIMP-1 in human periodontal ligament cells(HPDLC),and to unveil the molecular mechanism of ECM metabolism during periodontitis in diabetic.Method:HPDLC were cultured with AGEs.Expression of MMP-3 and TIMP-1 were determined by immunoflu-orescence and sandwich-in ELISA.Result:The expression of MMP-3 were significantly induced by AGEs.However,AGEs had no effect on the expression of TIMP-1.Conclusion:The results suggest that AGEs may affect ECM metabolism depend-ing on the functional role of MMP-3.
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