Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Changes in succinate dehydrogenase gene expression during 4-nitroquinoline 1-oxide induced rat tongue carcinogenesis.

GE Shu-yun,LOU Jia-ning,ZHOU Zeng-tong.1.Department of Oral Medicine,College of Stomatology,Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University;Research Institute of Stomatology;Shanghai Key Laboratory of Stomatology,Shanghai 200011,China;2.Department of Stomatology,First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China.  
Objective:To observe the different expression of Succinate dehydrogenase(SDH) during oral carcinogenesis,analyze the relationship between the abnormal expression of SDH,and the occurrence and development of oral carcinogenesis.Method:Real-time quantitative PCR was employed to detect the gene expression of SDH in 38 rat tongue carcinogenesis specimens induced by 4-nitroquinoline 1-oxide.Result:with the progress of tongue carcinogenesis,the expression of SDH was down-regulated.in normal,Mild epithelial dysplasia、Moderate epithelial dysplasia、severe epithelial dysplasia and squamous cell carcinoma(SCC).There was significant differences between normal and Moderate epithelial dysplasia、severe epithelial dysplasia and SCC,P 0.01 or P 0.05).There was a significant correlation between the decreased expression levels of SDH gene and histopathological grade(P 0.01).Conclusion:The down expression of SDH gene may be correlated to the occurrence and the development of oral carcinoma,suppressed Tricarboxylic acid cycle might in the development or progression of oral cancer.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved