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Dentin phosphoprotein in gingival crevicular fluid during early orthodontic root resorption in rats.

LI Wen-xing,LIU Yue-hua.Tongji University Sschool and Hospital of Stomatology,Shanghai 200072,China.  
Objective:This study aimed to establish the animal model of early orthodontic root resorption in rats,and determine whether dentin phosphoprotein(DPP) in gingival crevicular fluid(GFC) could serve as a prognostic factor for orthodontic root resorption.Method:46 12-week-old female SD rats were selected.The maxillary left first molar was drawn medially by applying an excess force.16 rats were killed and the sections were treated with HE and TRAP histochemistry in the aim of observing the root resorption.The other 30 rats were randomly divided into continuous force group(CF) and the force suspended group(IF) and GFC was collected.The concentrasion of DPP were assayed by using the biochemistry techniques of ELISA.Result:From 0d to 14d afterburner,concentration of DPP gradually increased,there were no significant differences between the two groups(P 0.05);from 14 d to 28 d,the concentration of DPP decreased in CF group,while it remained elevated on the 21th day,then reduced a little in IF group.The data between the two groups was statistically significant difference(P 0.01).The relative area of root resorption was correlated to the concentration of DPP,and the Pearson correlation coefficient was 0.618(P 0.05).Conclusion:DPP in GCF could be suitable biological marker for monitoring root resorption.
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