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The clinical and diagnosis analysis of chronic graft-versus-host disease in oral cavity.

TAO Ren-chuan1,XIAO Li-ting1,LAI Yong-rong2.1.Department of Periodontics and Oral Medicine,Stomatological Hospital,Guangxi Medical University,Guangxi Nanning 530021,China;2.Department of Hematology,First Affiliated Hospital,Guangxi Medical University,Guangxi Nanning 530021,China.  
Objective:We performed a systematic review on patients who developed chronic graft-versus-host disease in oral cavity after allogeneic hematopoietic stem cell transplantation,and to offer evidence to the diagnosis an treatment for graft-versus-host disease in oral cavity.Method:Studies on oral chronic graft-versus-host disease in allogeneic hematopoietic stem cell transplantation were selected from a wider search based on five electronic databases:PubMed database(1966-March 2010),EMBASE(1989-March 2010),Chinese Biomedical Database(1980-March 2010).No language restrictions were applied.According to our searching strategy and including criteria,35 studies were identified for analysis.Result:Literature shows that the oral chronic graft-versus-host disease has a higher prevalence and the oral manifestations were diverse.Diagnostic criteria is unclear yet.Conclusion:The commonest oral manifestation includes oral ulcers,erythema and lichen planus-like lesions among patients with chronic graft-versus-host disease.The majority of patients complained with pain and decreased salivary secretion.A better understanding on oral chronic graft-versus-host disease in clinical is needed in future,as wellas the diagnosis criteria needs to be modified further.
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