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The study of application of platelet-rich plasma in the treatment of periodontal intrabony defects.

ZHANG Li,GAO Jing,XIAO Chang-jie.The Department of Stomatology,Central Hospital of Taian City,Shandong Taian 271000,China.  
Objective:To establish a new method of isolating platelet-rich plasma(PRP) and the observation of its effects on the application in periodontal regeneration.Method:Platelet-rich plasma was isolated by two-step centrifugation(1000 rpm×15 min;3000 rpm×8 min) from 10 adults.Then the medium was dicarded and cells were exposed to 5 %,10 %,30 % PRP in 100 μL Alpha-MEM medium.To evaluate the effection of 5 %,10 %,30 % PRP and bone graft and bone graft only in periodontal regeneration.Result:This two-step centrifugation method sequestered and concentrated platelets to a level over four times baseline whole blood.PRP and bone graft can promoted periodontal regeneration.Conclusion:A convenient two-step centrifugation method of concentrating platelets was established.PRP produced by this technique and bone graft can promoted periodontal regeneration.At the dose of 5 %,10 %,30 % PRP promoted periodontal regeneration in a dose-dependant manner.
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