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《Journal of Clinical Stomatology》 2011-02
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Study of COX-2 expression and angiogenesis in salivary adenoid cystic carcinoma

LI Xiao-guang1,YUAN Li-li1,XIAO Chang-jie1,WANG Yan-xiu2.1.Department of Stomatology,Taian City Central Hospital,Shandong Taian 271000,China;2.Department of Anesthesiology,Taian City Central Hospital,Shandong Taian 271000,China.  
Objective:To explore the relationships between Cycloxygenase-2(COX-2) expression and angiogenesis in salivary adenoid cystic carcinoma(SACC).Method:The COX-2 expression,inducible nitric oxide synthase(iNOS) and vascular endothelial growth factor(VEGF) expression,microvessel density(MVD) were evalulated by immunohistochemical method.Result:The expressions of COX-2 and iNOS、VEGF in SACC were significantly positively correlated(P0.05,P0.01).There was significant difference of MVD between COX-2 positive SACC and negative ones(P0.05).Conclusion:The present findings suggest that there is some link between COX-2 and angiogenesis in SACC,partly attributing to the effect of VEGF and iNOS.
【Fund】: 泰安市科技局资助项目(2007-46)
【CateGory Index】: R739.8
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