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《Journal of Clinical Stomatology》 2011-02
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Detection and clinical benefits of keratinocyte growth factor KGF-1 in gingival crevicular fluid in the patients with periodontitis

ZHAO Zhe,WU Yun-xia,SUN Xiao-jun.Department of Stomatology,the First Affiliated Hospital of Shanxi Medical University,Shanxi Taiyuan,030001,China  
Objective:To detect the concentration of keratinocyte growth factor(KGF)-1 in gingival crevicular fluid(GCF) in the patients with chronic periodontitis before treatment and in different periods after treatment,to research the relationship between KGF-1 in GCF and periodontitis and the effect of KGF-1 in pathogenesis of periodontitis and its progressiveness.Method:The concentration of KGF-1 in GCF were detected by way of enzyme-linked immunosorbent assay following careful sampling of GCF with the standardized filter strips in healthy adults as well as periodontitis patients before treatment and in different stages after treatment.Result:The concentration of KGF-1 in GCF in the inflammatory group was significant higher than the normal group(P0.05),at the fourth week,sixth week and the eighth week after the treatment,the concentration of KGF-1 in GCF was lower than inflammatory group before treatment and significant deference of KGF-1 concentration and statistical significance were found before treatment and in different stages after treatment(P0.05).The concentration of KGF-1 in GCF was significantly associated with the probing depth、attachment loss and sulcus bleeding index.Conclusion:There is a close correlation between the level of KGF-1 in GCF and the degree of periodontal inflammation.The level of KGF-1 in GCF can be regarded as beneficial index that reflect the status of periodontitis.
【CateGory Index】: R781.4
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