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《Journal of Clinical Stomatology》 2011-02
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The influence of Qi-lan granulates on the variation of epidermal growth factor receptor during the course of SD rat tongue carcinogenesis

CHEN Zuo-liang1,HAN Yang-ping1,ZHENG Xaio-bin2,CHEN Hong-bo1,LIN Xiang-dang3.1.Dental Hospital of Xiamen,Fujian Medical University.Fujian Xiamen 361003,China;2.The People's Hospital of Quanzhou,Stomatological Department,Fujian Quanzhou 362000,China;3.Xiamen Research Insibitate of Medicine,Fujian Xiamen 361003,China.  
Objective:To study the cancer blocking effect of the Qi-lan Granulates.Method:A total of 150 SD rats were divided into five groups A,B,C,D,E.Rats in group A,B,C,D were fed with 0.002 % 4NQO dissolved in drinking water to induce tongue carcinogenesis in rats.Different concentration of the herb Qi-lan Grannulates was given to the rats of group B,C,D during oral carcinogenesis.Group A is model group,Group E is normal group.Rats were sacrificed at 9,18,27 and 36 weeks respectively from the begining of the experiment.The samples were collected for histophology and EGFR immunohistochemistry.The date were analyzed by Chi-square test and Kruskal-Wallis test.Result:The overall canceration rate of group B,C,D is lower than group A(39.29 %)(P0.05),In group A the expression of EGFR:normal tissuedysplasia tissuetongue cancer tissue(P0.05).The expression rate of EGFR in tongue dysplasia from rats in group A(6/11) is significantly higher than anthor groupsB、C、D(P0.05).But in cancer tissue of from rats,the expression of EGFR in group A was significantly higher than group B、C、D(P0.05).the difference was statistically significant(P0.05).the expression of EGFR in group E was negative.Conclusion:Qi-lan granulates have significant inhibitory effects of cancer,he may cut through epidermal growth factor receptor level to block cancerous.
【Fund】: 厦门市科技计划项目资助(3502Z20044008)
【CateGory Index】: R739.8
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