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《Journal of Clinical Stomatology》 2011-06
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Effect of N-acetylcysteine on biocopatibility of dentin adhesives

DU Shan-shan,ZHOU Juan,XIE Long-chuan,CAI Hong-bo,LUO Zhi-xiao.Department of Stomatology,Affiliated Taihe Hospital of Hubei University of Medicine,Hubei Shiyan 442000,China.  
Objective:To evaluate the potential amelioration of the cytotoxicity of two dental adhesives(Prime Bond NT and Single Bond 2) by N-acetyl cysteine(NAC) in vitro.Method: Specimens of tested adhesives were light-cured and placed in the culture medium for 24 h.3T3-Swiss albino(3T3) cells were exposed to the extraction mediums in the presence and absence of NAC for 24 hrs.Cytotoxicity was measured with a modified 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide(MTT) assay.Result:The tested adhesives exhibited cytotoxic effect,and the adhesives-induced cytotoxicity was significantly improved by co-treatment with 5 mM of NAC(P 0.05).Conclusion:NAC exhibited notable detoxification effects on the tested commercial adhesives.
【CateGory Index】: R781.05
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