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《Journal of Clinical Stomatology》 2011-12
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Osteoinductive potential of collagen membrane incorporated with SIC in skull defects of rats

LIU Tian-hong1,XIE Wei-li1,SU Da-wei2.1.Department of Prosthetics,School of Stomatology,Harbin Medical University,Heilongjiang Harbin 150001,China;2.School of Materials Science and Technology,Harbin Institute of Technology,Heilongjiang Harbin 150001,China.  
Objective:The aim of the experimental study was to evaluate the effect of sic incorporated membrane(SIM) in repairing skull trephined defects in rats.Method:Sic incorporated membrane was repared.Inorder to make the GTR animal model.Three 5mm trephined defects was made in the skull of each rat.Three defects were processed in different ways respectively:①covered by SIM on the dura and the pericrania defect;②covered by SIM on the pericrania defect only;③covered by collagen membrane on the pericrania;④filled with autogenous blood only as control.The defect sites were studied histologically in 4 weeks after operation.Result:The histomorphometric analysis showed significantly more bone bridging area in SIM defects than that in membrane defects and control defects(P 0.01).And there was significantly more bone bridging area in biSIM defects than that in unilateral SIM defects(P 0.01).Conclusion:SIM-incorporated membrane(SIM) was an ideal GTR membrane to have mechanical barrier and have potential osteoinduction.
【Fund】: 国家高技术研究发展计划(863计划):(2007AA03Z340);; 黑龙江省卫生厅科研课题(2005-184);; 黑龙江省教育厅科研课题(1151184)
【CateGory Index】: R318.08
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