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《Journal of Clinical Stomatology》 2011-12
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Altered telomerase activity in X-ray induced Tca8113 cells

XIE Qian1,HUANG Hong-zhang2,HU Xiao-wen2,HE Ling-fei1.1.Department.of Stomatology,the First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Guangzhou 510080,China;2.Department.of Oral and Maxillofacial Surgery,Oral Subsidiary Sun Yat-sen University Hospital,Guangdong Guangzhou,510055,China;3.Department of Implantology,Oral Subsidiary Sun Yat-sen University Hospital,Guangdong Guangzhou,510055,China.  
Objective:Human telomerase,a unique reverse transcriptase,is the one of ribonucleoprotein complexes,which is composed of ubiquitously expressed RNA subunit,telomerase RNA component and a protein catalytic subunit.It can synthesize telomeric repeat sequence.Telomease activity(TA) is present in almost all human immortal cell lines.Radiotherapy is the important part in therapy for oral cancer The aim of this study is to investigate TA in X-ray induced Tca8113 cells.Method:Tca8113 cells cultured in vitro were irradiated with 0,2,4,8,12 or 20 Gy of X-ray.TARP was performed to detect TA in Tca8113 cells incubated for 0.5 h,1 h,3 h or 5 h after exposure to various doses of X-ray irradiation.Result:TA was positive in non-irradiated Tca8113 cells.TA decreased apparently in Tca8113 cells treated with 2 Gy of X-ray radiation and was not detectable in other groups.Conclusion :TA was positive in Tca8113 cells and dose-dependently down-regulated by 2 Gy of X-ray irradiation.TA may be essential to survival of irradiated Tca8113 cells in vitro.
【CateGory Index】: R739.8
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 ZOU Yue*, ZHOU Xiang-yan, DU Wei-xia, et al. *The PLA Second Artillery General Hospital, Beijing 100088,China;Study on telomere lengthening induced by radiation[J];Chinese Journal of Radiation Mediation and Protection;2005-06
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3 XIE Qian 1 ,HUANG Hong-zhang 1 ,WEI Jing 2 ,MAO Yong-lin 3 ,HU Xiao-wen 1 ,YU Dong-sheng 1 (1.Department of Oral &Maxillofacia l Surgery,2.Lin Bai-xin Research Ce nter,3.Department of Oncology,The Second Affiliated Hospital,SUN Yat-sen University,Guangzhou 510120,China);Dynamic Observation on Effect of X-ray on Telomere Length in Squamous Cell Carcinoma Tongue Tca8113 Cell Line[J];Journal of Sun Yat-sen University (Medical Sciences);2004-05
4 Zhou Jun,Jin Yan Department of Oral Pathology, Stomatological College, The Fourth Military Medical University, Xi'an 710032 He Yong Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032;THE RELATIONSHIP OF TELOMERASE ACTIVITY AND SQUAMOUS CELL CARCINOMA OF ORAL[J];China Journal of Modern Medicine;2003-18
【Co-citations】
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1 Zuo Yahui Dang Xuhong(China Institute for Radiation Protection,Taiyuan,030006);Potential Biological Implications of Ionizing Radiation Induced Non-targeted Effects[J];Radiation Protection Bulletin;2010-04
2 WANG, Jie-Xin WEN, Li-Xiong HE, Ping CHEN, Jian-Feng* (Key Lab for Nanomaterials, Ministry of Education, Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029);Study on a Novel Template Synthesis Method for Hollow Silica Nanospheres[J];Acta Chimica Sinica;2005-14
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4 Li Liu, Ji-Wen Xie, Xi Wang, Department of Integrated Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China Ye-Ming Xie, College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, Hubei Province, China;EGCG in combination with radiotherapy down-regulates hTERT expression in HepG2 cells[J];World Chinese Journal of Digestology;2010-18
5 ZOU Yue, LI Zhi_ren, ZHOU Xiang-yan, et al. The PLA Second Artillery General Hospital, Beijing 100088,China;Effect of RNAi inhibiting telomerase on telomere lengths after irradiation[J];Chinese Journal of Radiological Medicine and Protection;2006-05
【Secondary Citations】
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1 ZOU Yue SUN Mingzhu ZHOU Xiangyan (The PLA Second Artillery General Hospital, Beijing 100088) (Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Bejiing 100088);Telomerase expression and its activity in human tumor and normal cell lines during radiation-induced apoptosis[J];Journal of Radiation Research and Radiation Processing;2003-04
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