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《Journal of Clinical Stomatology》 2011-12
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Effects of HAART on the prevalence of cytomegalovirus,herpesviruses 6,7 and 8 in saliva from human immunodeficiency virus-seropositive subjects

GE Liu-ying1,LI Cheng-wen2,BAI Jin-song3,SHI Hui-ping1,LI Rong1,LI Chong-xi3,DUAN Kai-wen1.1.Department of Dentistry The Yanan Hospital Affiliated to Kunming Medical University,Kunming City Yanan Hospital,Yunnan Kunming 650051,China;2.Department of Research Management,The Third Hospital Affiliated to Kunming Medical University,Yunnan Kunming 650118,China;3.Department of Infectious Diseases Kunming City Third Hospital,Yunnan Kunming 650041,China.  
Objective:This study aimed to determine the presence of CMV,HHV-6,HHV-7 and HHV-8 and HHV-8 in the saliva of HIV-seropositive patients with HAART and non-HAART.Method:CMV,HHV-6,HHV-7 and HHV-8 DNA of Unstimulated whole saliva from 245 HIV-infected patients and 30 healthy HIV-seronegative controls were analyzed by nested-PCR assays.The data was analyzed by the use of SPSS Statistical software version 18.0.Result:There was no difference of detection rates of these four HHVs in saliva between HIV patients with HAART group and non-HAART group(P 0.05).HAART group,non-HAART group compared with the normal group differences,and the three groups are present CMV,HHV-6,HHV-7 and HHV-8 multiple infections.Conclusion:Oral herpesvirus infection in patients with HIV infection is very common,of which the most prominent are HHV-6 and HHV-7.Saliva may play a possible role in HHVs spread.
【Fund】: 国家自然科学基金资助项目(30860315 81160135);; 云南省应用基础研究资助项目(2008ZC146M)
【CateGory Index】: R512.91
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