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《Journal of Clinical Stomatology》 2014-01
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Effect of sleep deprivation on levels of serum hormone and inflammation indicators of masseter muscle in rat

WANG Pei-huan;WU Gao-yi;ZHU Guo-xiong;Department of Stomatology,General Hospital of Jinan Militar Command;  
Objective:To observe the effect of sleep deprivation on levels of serum hormone and inflammation indicators of masseter muscle in rat,and to investigate the effect of sleep deprivation upon the pathogenesis of TMD. Method:35 Wistar rats were randomly divided into five groups:normal cage control group,tank control group, SD1d group,SD 5 d group,and SD 9 d group. Then "modified multiple plat-form method" was used to develop rat sleep deprivation model followed by detection of contents of CORT,ACTH and TSH in serum and hs-CRP in masseter muscle of rat. Result:Compared with those in the normal cage control and tank control group,the contents of CORT,ACTH and TSH was first increased and then decreased with the elongation of sleep deprivation time, but the contents of hs-CRP showed a continuously increasing tendency. Conclusion: Sleep deprivation contributes to inflammatory reaction of rat masseter muscle, serving as a potential etiology of TMD.
【Fund】: 第48批中国博士后科学基金(2010048152);; 第4批中国博士后特别资助基金(201104771);; 山东省中青年科学家奖励基金(2011BSBO2001);; 济南军区总医院院长基金(2010M08)
【CateGory Index】: R338
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
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