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《Journal of Clinical Stomatology》 2014-10
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Fabrication of PEI/PLGA nanofibers by coaxial electrospinning

XU Hong-yu;JIA Lie-ni;GUO Qiu-yun;DONG Yu;HU Xiang-gang;JIA Jun;State Key Laboratory of Military Stomatology,Department of Prosthodontics,School of Stomatology,Fourth Military Medical University;Department of Stomatology,People’s Hospital of Hainan Province;  
Objective:To prepare a novel poly(lactic-co-glycolic acid)(PLGA)/Polyethylenimine(PEI)coresheath structured composite membrane by coaxial electrospinning,evaluate PLGA / PEI fiber morphology and related properties,we provided the basis for scaffold on tissue engineering. Method:By using the technology of coaxial electrospinning,fiber membranes with shell of PLGA and core of PEI were prepared. Then we observed the morphologyo,detected the coaxial structure,investigated hydrophilicity and measured the mechanical properties of the fibers. Result:The coaxial structure fiber diameter is uniform distribution and the surface of fibers was smooth. The diameter,the hydrophilic absorption and the mechanical properties were different from fiber membranes with PLGA. Conclusion:The PEI/PLGA fiber was prepared;at the same time the fiber indicate the well prospects on the field of tissue engineering.
【Fund】: 国家自然科学基金资助(81271136)
【CateGory Index】: R318.08
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