Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical Stomatology》 2014-10
Add to Favorite Get Latest Update

Research on expression and significance of Cosmc,T antigen and VEGFR/KDR during different phases of infantile hemangiomas

TANG Guo-xiong;LI Qin;TAO Xue-jin;ZHU Sheng-rong;ZHOU Lei-lei;XIE San-xiang;Center of Stomatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology;  
Objective:To investigate the expression of Cosmc,T antigen and VEGF R/KDRin different phases of infantile hemanginomas,and analyze the significance of the differerces. Method:Forty-five samples of infantile hemangioma tissue,excised in operation,and 10 normal controls were evaluated the expression of Cosmc,T antigen and VEGFR/KDR by immunohistochemistry. All thirty samples of infantile hemangioma,proved by pathologic method, were divided into proliferative and involuting groups,according to the Mulliken standard. Result:(1)Cosmc,T antigen and VEGFR/KDR showed an overexpression rate in proliferating infantile hemangiomas compared with involuting ones. The expression in the proliferative and involuting groups was significantly different(P 0.05),compared with the controls separately.(2)T antigen in IH showed positive correlation with Cosmc(r=0.50,P 0.01).(3)VEGFR/KDR in IH showed positive correlation with T antigen(r=0.53,P 0.01). Conclusion:Cosmc,T antigen and VEGFR/KDR may play key roles in the development of infantile hemangiomas,and a new theory for the development and prognosis of infantile hemangiomas may be provided.
【Fund】: 湖北省自然科学基金(2011CHB012)
【CateGory Index】: R732.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Liu Yun;Ye Jun;Song Lili;Tian Yin;Pan Qiong;Peng Zhihong;Wang Rongquan;Institute of Gastroenterology,Southwest Hospital,Third Military Medical University;;Core 2 and Core 4 O-glycan chains participate in adhesion and invasion of E. coli to intestinal epithelial cells in vitro[J];Journal of Third Military Medical University;2014-02
2 ;Recent progress in studies of pathogenesis of infantile hemangioma[J];Chinese Journal of Aesthetic Medicine;2013-20
3 Lu-Gang Yu,The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology,Division of Gastroenterology,School of Clinical Sciences and Liverpool Centre for Glycobiology,University of Liverpool,Liverpool L69 3GE,United Kingdom;Circulating galectin-3 in the bloodstream:An emerging promoter of cancer metastasis[J];世界胃肠肿瘤学杂志(电子版)(英文版);2010-04
4 Kristel Kodar, Jelena Izotova, Kersti Klaamas, Boris Sergeyev, Lilian Jrvekülg, Oleg Kurtenkov , Department of Oncology and Immunology, National Institute for Health Development, 11619 Tallinn, Estonia, Tallinn University of Technology, Institute of Gene Technology, 12618 Tallinn, Estonia;Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients[J];世界胃肠病学杂志(英文版);2013-23
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved