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《Journal of Clinical Stomatology》 2014-10
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Research on expression and significance of Cosmc,T antigen and VEGFR/KDR during different phases of infantile hemangiomas

TANG Guo-xiong;LI Qin;TAO Xue-jin;ZHU Sheng-rong;ZHOU Lei-lei;XIE San-xiang;Center of Stomatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology;  
Objective:To investigate the expression of Cosmc,T antigen and VEGF R/KDRin different phases of infantile hemanginomas,and analyze the significance of the differerces. Method:Forty-five samples of infantile hemangioma tissue,excised in operation,and 10 normal controls were evaluated the expression of Cosmc,T antigen and VEGFR/KDR by immunohistochemistry. All thirty samples of infantile hemangioma,proved by pathologic method, were divided into proliferative and involuting groups,according to the Mulliken standard. Result:(1)Cosmc,T antigen and VEGFR/KDR showed an overexpression rate in proliferating infantile hemangiomas compared with involuting ones. The expression in the proliferative and involuting groups was significantly different(P 0.05),compared with the controls separately.(2)T antigen in IH showed positive correlation with Cosmc(r=0.50,P 0.01).(3)VEGFR/KDR in IH showed positive correlation with T antigen(r=0.53,P 0.01). Conclusion:Cosmc,T antigen and VEGFR/KDR may play key roles in the development of infantile hemangiomas,and a new theory for the development and prognosis of infantile hemangiomas may be provided.
【Fund】: 湖北省自然科学基金(2011CHB012)
【CateGory Index】: R732.2
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