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《Journal of Clinical Stomatology》 2014-10
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Study on the expression of α-SMA in human umbilical vein endothelial cells induced by arecoline

ZHOU Ye-ye;LING Tian-you;Dental Center of the Second Xiangya Hospital of Central South University;  
Objective:To test how losartan inhibits the expression of α-SMA protein in Human Umbilical Vein Endothelial Cells(HUVECs),which stimulated by arecoline. Method:With different concentrations of arecoline stimulate HUVECs,respectively,detected the expression of α-SMA in HUVECs using the method of Western Blot. Then With certain concentrations of arecoline induce HUVECs,making different concentrations of losartan stimulate HUVECs,respectively,detected the expression of α-SMA in HUVECs. Result:HUVECs can express α-SMA induced by Arecoline,and the the expression of α-SMA can be inhibited after the stimulation of losartan. Conclusion:HUVECs stimulated by arecoline transformed into myofibroblast expressing the α-SMA. And AT1 R inhibitor can inhibit this transformation to some extent,which suggesting that AngⅡ and AT1 R may play roles in the endothelial-to-mesenchymal transition induced by arecoline.
【CateGory Index】: R781.5
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【Citations】
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1 LIU Hongfang 1,2 LIN Xiaofeng 1,2 XU Luli 1,2 CHENG Zhiyun 1,2 LV Yinghui 1,2 1.Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China; 2.Molecular Medicine Engineering Research Center, Quanzhou 362021,China;Progress in development of anti-hepatic fibrosis drug[J];China Medicine and Pharmacy;2011-20
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