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《Journal of Clinical Stomatology》 2014-10
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Clinical research for preoperative chemotherapy,radiotherapy combined with surgery to treat middle-late squamous cell carcinoma of oral

FU Sheng;FAN Li-na;ZHOU Wen-tu;Department of Stomatology,Fuzhou General Hospital of Nanjing Military Command;  
Objective:To investigate the clinical effect of the integrated program of preoperative chemotherapy,radiotherapy combined with surgery to cure middle-late squamous cell carcinoma of oral. Method:A total of 104 biopsy confirmed cases from our hospital,were included in this research. The patients needed to accept preoperative chemotherapy and the radiotherapy for 1 cycle. And then the combined radical operations started. The clinical effect was researched in aspects of local recurrence rate,distant metastasis rate,survival rate,quality of life,mouth opening,and titanium rejection,infection,fracture and so on. Result:The effective rate of preoperative chemotherapy and radiotherapy to treat middle-late squamous cell carcinoma of oral was 98.08%.The rate of surgery resection after preoperative induced chemotherapy and preoperative radiotherapy was 100 % with less postoperative adverse reactions. The local recurrence rate was only 1.92 %(2 cases). The distant metastasis rate was only 2.88 %(3 cases). The rate of titanium rejection and infection reaction that leads to restriction of mouth opening was only 2.88 %(3 cases). The 5-year survival rate after operation was 91.35 %(95 cases). Cnclusion:Preoperative chemotherapy and radiotherapy have a good clinical effect in positive anti-tumor,providing a good foundation for further surgical treatment.The integrated program of preoperative induced chemotherapy,preoperative radiotherapy combined with surgery can raise the long-term survival rate,surgery resection rate and has little adverse reactions.It would be worthy of disseminating and applying for the comprehensive treatment of middle-late squamous cell carcinoma of oral and maxillofacial region.
【CateGory Index】: R739.85
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