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Fas Antigen Expression and Significance in Squamous Cell Carcinoma of Buccal Mucosa.

Jiang Hongbin et al. Department of Stomatology,Affiliated Hospital of Wannan Medical College(241001).  
To study Fas antigen expression and its biological significance in squamous cell carcinoma of buccal mucosa(SCCBM),immunohistochemical staining with anti-Fas was used to detect the Fas antigen in specimens obtained from 5 cases of human buccal mucosa and 34 cases of SCCBM.The results showed that Fas antigen was intermittently expressed on the stratum germinativum of buccal mucosa epithelium,but consistently around the cell membrane of the other stratum;and Fas antigen expression was significantly correlated with the differentiation degree of SCCBM( P 0.01),strongly positive staining in well-differentiated tumors,weakly plsitive staining in poor-differentiated tumors.The present results suggest Fas antigen expression may not only be related to the physiological differentiation maturation and death of epithelial cell in buccal mucosa,but also play roles in the pathological differentiation and de-differentiation of SCCBM.
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