Immunohistochemical study on oral and maxillofacial fixed drug eruptions.
Li Jian cheng et al. First Hospital of Ninde Profecture Fujian Provice, Fuan 355000
This artical reports 18 patients with oral and maxillofacial fixed drug eruptions(FDE);10 cases were tested immunohistochemically with different mouse anttihuman monoclonal antibodies(McAb) to identify T lymphocytes,their phenotypic subsets and B lymphocytes 70 to 80% of lymphocytes perivasculary infiltrating the superficial dermis were found to be T cell. CD 4 -positive cells and CD 8 -positive cells were approximately equal among the pan-T-positive cells. CD 8 positive cells were more active in exocytosis than CD 4 -postitiv cell, In addition,about 15% dermal infiltration cells were B-positive lymphocytes. These results indicated that T inducer/helper and suppressor/cytotoxic cells might play a major role in mediating the inflammatory reactionin FDE.